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The angel said to her, "Do not be afraid, Mary, for you have found favor with God. And now you will conceive in your womb and bear a son, and you will name him Jesus. Mary said to the angel, "How can this be, since I am a virgin?" The angel said to her, "The Holy Spirit will come upon you, and the power of the Most High will overshadow you; therefore the child to be born will be holy; he will be called the Son of God... For nothing will be impossible with God. (Luke 1:30ff.
"How can this be?" There is a lot to that question. On the one hand, Mary is certainly asking how it is that she will get biologically from point "A" to point "B". What the angel told her was indeed perplexing news. It was news that didn't at all suggest a standard route to having a child. It didn't make sense to Mary. It wouldn't have made sense to any of us either. Mary had every reason to be perplexed.